Unlocking the Medicinal Benefits of Local Herbal Remedies
Benefit of local herbal
Downloads
This study explores the medicinal potential of indigenous herbs in Southeast Asia. They are categorized herbs based on their flavor, taxonomy, and plant part, with an emphasis on their wide-ranging applications. The discussion focuses on five key herbs: Tongkat Ali, Misai Kucing, Hempedu Bumi, Kacip Fatimah, and Limau Purut, all of which are renowned for their specific therapeutic benefits. While these herbs offer promising medicinal properties, precautions must be exercised due to the potential for adverse effects and interactions. The findings of previous research shed light on the rich medicinal heritage of local herbs, providing valuable insights for future studies and pharmaceutical development. This review comprehensively discusses both the benefits and precautions associated with the use of local herbs.
Abd Aziz, N. A., Hasham, R., Sarmidi, M. R., Suhaimi, S. H., & Idris, M. K. H. (2021). A review on extraction techniques and therapeutic value of polar bioactives from Asian medicinal herbs: Case study on Orthosiphon aristatus, Eurycoma longifolia and Andrographis paniculata. Saudi Pharmaceutical Journal, 29(2), 143–165.
https://doi.org/10.1016/j.jsps.2020.12.016
Abd-Elaziem Farouk, & Asma Benafri. (2007). Antibacterial activity of Eurycoma longifolia Jack. A Malaysian medicinal plant. Saudi Med J . , 28(9), 1422–1424.
Abdul Kadir, A., Nik Hussain, N. H., Wan Bebakar, W. M., Mohd, D. M., Wan Mohammad, W. M. Z., Hassan, I. I., Shukor, N., Kamaruddin, N. A., & Wan Mohamud, W. N. (2012). The Effect of Labisia pumila var. alata on Postmenopausal Women: A Pilot Study. Evidence-Based Complementary and Alternative Medicine, 2012, 1–6.
https://doi.org/10.1155/2012/216525
Abirami, A., Nagarani, G., & Siddhuraju, P. (2014). In vitro antioxidant, anti-diabetic, cholinesterase and tyrosinase inhibitory potential of fresh juice from Citrus hystrix and C. maxima fruits. Food Science and Human Wellness, 3(1), 16–25. https://doi.org/10.1016/j.fshw.2014.02.001
Akowuah, G. A., Ismail, Z., Norhayati, I., & Sadikun, A. (2005). The effects of different extraction solvents of varying polarities on polyphenols of Orthosiphon stamineus and evaluation of the free radical-scavenging activity. Food Chemistry, 93(2), 311–317. https://doi.org/10.1016/j.foodchem.2004.09.028
Almeida, J. C. (1996). Coma from the Health Food Store: Interaction between Kava and Alprazolam. Annals of Internal Medicine, 125(11), 940. https://doi.org/10.7326/0003-4819-125-11-199612010-00023
Ashraf, K., Sultan, S., & Adam, A. (2018). Orthosiphon stamineus Benth. is an outstanding food medicine: Review of phytochemical and pharmacological activities. Journal of Pharmacy And Bioallied Sciences, 10(3), 109.
https://doi.org/10.4103/JPBS.JPBS_253_17
Boozer, C., Daly, P., Homel, P., Solomon, J., Blanchard, D., Nasser, J., Strauss, R., & Meredith, T. (2002). Herbal ephedra/caffeine for weight loss: a 6-month randomized safety and efficacy trial. International Journal of Obesity, 26(5), 593–604. https://doi.org/10.1038/sj.ijo.0802023
Boullata, J. I., & Nace, A. M. (2000). Safety Issues with Herbal Medicine. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 20(3), 257–269.
https://doi.org/10.1592/phco.20.4.257.34886
Bravo, L. (2009). Polyphenols: Chemistry, Dietary Sources, Metabolism, and Nutritional Significance. Nutrition Reviews, 56(11), 317–333.
https://doi.org/10.1111/j.1753-4887.1998.tb01670.x
Buran Phansawan, & Supak Poungbangpho. (2007). Antioxidant Capacities of Pueraria mirifica, Stevia rebaudiana Bertoni, Curcuma longa Linn., Andrographis paniculata (Burm.f.) Nees. and Cassia alata Linn. for the Development of Dietary Supplement. Agriculture and Natural Resources, 41(3), 548–554.
C Kuppusamy, & K Murugan. (2010). Effects of Andrographis paniculata Nees on growth, development and reproduction of malarial vector Anopheles stephensi Liston (Diptera: Culicidae). Tropical Biomedicine, 27(3), 509–516.
Chen, W.-L., Tsai, T.-H., Yang, C. C. H., & Kuo, T. B. J. (2010). Acute Effects of Ephedra on Autonomic Nervous Modulation in Healthy Young Adults. Clinical Pharmacology & Therapeutics, 88(1), 39–44. https://doi.org/10.1038/clpt.2010.66
Chinese Pharmacopoeia Commission. (2010). Pharmacopoeia of the People’s Republic of China (English edition). Ministry of Health of the People’s Republic of China.
Chong, S. K. F., & Oberholzer, V. G. (1988). Ginseng--is there a use in clinical medicine? Postgraduate Medical Journal, 64(757), 841–846. https://doi.org/10.1136/pgmj.64.757.841
Chua, L. S., Latiff, N. A., Lee, S. Y., Lee, C. T., Sarmidi, M. R., & Aziz, R. A. (2011). Flavonoids and phenolic acids from Labisia pumila (Kacip Fatimah). Food Chemistry, 127(3), 1186–1192. https://doi.org/10.1016/j.foodchem.2011.01.122
Craig, W. J. (1999). Health-promoting properties of common herbs. The American Journal of Clinical Nutrition, 70(3), 491S-499S.
https://doi.org/10.1093/ajcn/70.3.491s
Damsch, S., Eichenbaum, G., Looszova, A., Lammens, L., Feyen, B., Bulck, K. Van den, Knight, E., Kelley, M., & Tonelli, A. (2011). Unexpected Nasal Changes in Rats Related to Reflux after Gavage Dosing. Toxicologic Pathology, 39(2), 337–347. https://doi.org/10.1177/0192623310388430
Damsch, S., Eichenbaum, G., Tonelli, A., Lammens, L., Bulck, K. Van den, Feyen, B., Vandenberghe, J., Megens, A., Knight, E., & Kelley, M. (2011). Gavage-Related Reflux in Rats. Toxicologic Pathology, 39(2), 348–360.
https://doi.org/10.1177/0192623310388431
Dan Bensky, Steven Clavey, & Erich Stöger. (2004). Chinese Herbal Medicine: Materia Medica (3rd ed.). WA: Eastland Press.
Das, S. C., Prakash, J., Deb, A. K., & Biswas, T. (2013). Medicinal value of underutilized fruits in hilly tripura. Acta Horticulturae, 972, 135–141. https://doi.org/10.17660/ActaHortic.2013.972.17
Dunnick, J. K., & Nyska, A. (2013). The Toxicity and Pathology of Selected Dietary Herbal Medicines. Toxicologic Pathology, 41(2), 374–386. https://doi.org/10.1177/0192623312466451
Edgar, J. A., Colegate, S. M., Boppré, M., & Molyneux, R. J. (2011). Pyrrolizidine alkaloids in food: a spectrum of potential health consequences. Food Additives & Contaminants: Part A, 28(3), 308–324. https://doi.org/10.1080/19440049.2010.547520
Fathilah, S. N., Mohamed, N., Muhammad, N., Mohamed, I. N., Soelaiman, I. N., & Shuid, A. N. (2013). Labisia pumila regulates bone-related genes expressions in postmenopausal osteoporosis model. BMC Complementary and Alternative Medicine, 13(1), 217. https://doi.org/10.1186/1472-6882-13-217
Hackman, R. M., Havel, P. J., Schwartz, H. J., Rutledge, J. C., Watnik, M. R., Noceti, E. M., Stohs, S. J., Stern, J. S., & Keen, C. L. (2006). Multinutrient supplement containing ephedra and caffeine causes weight loss and improves metabolic risk factors in obese women: a randomized controlled trial. International Journal of Obesity, 30(10), 1545–1556. https://doi.org/10.1038/sj.ijo.0803283
Hallas, J., Bjerrum, L., Stovring, H., & Andersen, M. (2008). Use of a Prescribed Ephedrine/Caffeine Combination and the Risk of Serious Cardiovascular Events: A Registry-based Case-Crossover Study. American Journal of Epidemiology, 168(8), 966–973. https://doi.org/10.1093/aje/kwn191
Haller, C., JACOBIII, P., & BENOWITZ, N. (2005). Short-term metabolic and hemodynamic effects of ephedra and guarana combinations. Clinical Pharmacology & Therapeutics, 77(6), 560–571. https://doi.org/10.1016/j.clpt.2005.01.023
He, B., Gao, J., Luo, X., Luo, J. et. al. (2011). Ginsenoside Rg3 inhibits colorectal tumor growth through the down-regulation of Wnt/ß-catenin signaling. International Journal of Oncology, 38(2). https://doi.org/10.3892/ijo.2010.858
Hendra, R., Ahmad, S., Oskoueian, E., Sukari, A., & Shukor, M. Y. (2011). Antioxidant, Anti-inflammatory and Cytotoxicity of Phaleria macrocarpa (Boerl.) Scheff Fruit. BMC Complementary and Alternative Medicine, 11(1), 110. https://doi.org/10.1186/1472-6882-11-110
Hickmann M.A. (2003). The Food and Drug Administration (FDA) (Hickmann M. A., Ed.). Nova Science Publishers.
Hossain, M. A., & Ismail, Z. (2010). High performance thin layer chromatographic determination of caffeic acid and rosmarinic acid from the leaves of Orthosiphon stamineus. Indonesian Journal of Chemistry, 9(1), 137–141. https://doi.org/10.22146/ijc.21575
Jadhao D., & Thorat B. (2014). Purification (crystallization) of biotactive ingredient andrographolide from Andrographis paniculata. World Journal of Pharmacy and Pharmaceutical Sciences, 3, 747–763.
Jang, D.-J., Kim, S. T., Oh, E., & Lee, K. (2014). Enhanced oral bioavailability and antiasthmatic efficacy of curcumin using redispersible dry emulsion. Bio-Medical Materials and Engineering, 24(1), 917–930. https://doi.org/10.3233/BME-130886
Karimi, E., Jaafar, H. Z., & Ahmad, S. (2013). Antifungal, anti-inflammatory and cytotoxicity activities of three varieties of Labisia pumila benth: from microwave obtained extracts. BMC Complementary and Alternative Medicine, 13(1), 20. https://doi.org/10.1186/1472-6882-13-20
Khanijo, T., & Jiraungkoorskul, W. (2016). Review ergogenic effect of long jack, Eurycoma longifolia. Pharmacognosy Reviews, 10(20), 139. https://doi.org/10.4103/0973-7847.194041
Kim, E. J. Y., Chen Y., Huang J. Q., Li K. M., Valentina R. N., Poon J., Chan K., Roufogalis B. D., McLachlan A. J., Mo, S.-L., Yang D., Yao M., Liu Z., Liu J., & Li G. Q. (2013). Evidence-based toxicity evaluation and scheduling of Chinese herbal medicines. Journal of Ethnopharmacology, 146(1), 40–61. https://doi.org/10.1016/j.jep.2012.12.027
Kim, H.-J., Park, J.-M., Kim, J.-A., & Ko, B.-P. (2008). Effect of Herbal Ephedra sinica and Evodia rutaecarpa on Body Composition and Resting Metabolic Rate: A Randomized, Double-blind Clinical Trial in Korean Premenopausal Women. Journal of Acupuncture and Meridian Studies, 1(2), 128–138. https://doi.org/10.1016/S2005-2901(09)60033-9
Kim, J.-W., Jung, S.-Y., Kwon, Y.-H., Lee, J.-H., Lee, Y. M., Lee, B.-Y., & Kwon, S.-M. (2012). Ginsenoside Rg3 attenuates tumor angiogenesis via inhibiting bioactivities of endothelial progenitor cells. Cancer Biology & Therapy, 13(7), 504–515. https://doi.org/10.4161/cbt.19599
Lim, T. K. (2015). Edible Medicinal and Non Medicinal Plants. Springer Netherlands. https://doi.org/10.1007/978-94-017-9511-1
Mansor, C. N. A. N. C., Latip, J., & Markom, M. (2016). Preparation of Orthosiphon stamineus enriched-extracts and evaluation of their free radical scavenging activity. 030013.
https://doi.org/10.1063/1.4966751
Menzel, D. C. (1998). www. ethics. gov: Issues and Challenges Facing Public Managers. Public Administration Review, 58(5), 445.
https://doi.org/10.2307/977553
Mishra, K., Dash, A. P., & Dey, N. (2011). Andrographolide: A Novel Antimalarial Diterpene Lactone Compound from Andrographis paniculata and Its Interaction with Curcumin and Artesunate. Journal of Tropical Medicine, 2011, 1–6. https://doi.org/10.1155/2011/579518
Moawad, F. J., Hartzell, J. D., Biega, T. J., & Lettieri, C. J. (2006). Transient Blindness Due to Posterior Reversible Encephalopathy Syndrome Following Ephedra Overdose. Southern Medical Journal, 99(5), 511–514. https://doi.org/10.1097/01.smj.0000215739.90211.3b
Nadia, M. E., Nazrun, A. S., Norazlina, M., Isa, N. M., Norliza, M., & Ima Nirwana, S. (2012). The Anti-Inflammatory, Phytoestrogenic, and Antioxidative Role of Labisia pumila in Prevention of Postmenopausal Osteoporosis. Advances in Pharmacological Sciences, 2012, 1–7.
https://doi.org/10.1155/2012/706905
Nag, S. A. (2012). Ginsenosides as anticancer agents: In vitro and in vivo activities, structure–activity relationships, and molecular mechanisms of action. Frontiers in Pharmacology, 3. https://doi.org/10.3389/fphar.2012.00025
Norhaiza M., Maziah M., & Hakiman M. (2009). Antioxidative properties of leaf extracts of a popular Malaysian herb, Labisia pumila. Journal of Medicinal Plants Research, 3(4), 217–223.
Nurdiana, N., Mariati, N., Noorhamdani, N., Setiawan, B., Budhiparama, N., & Noor, Z. (2018). Effects of Labisia pumila on bone turnover markers and OPG/RANKL system in a rat model of post-menopausal osteoporosis. Clinical Nutrition Experimental, 20, 41–47.
https://doi.org/10.1016/j.yclnex.2018.01.002
Pushpalatha, E., & Muthukrishnan, J. (1995). Larvicidal activity of a few plant extracts against Culex quinquefasciatus and Anopheles stephensi. Indian Journal of Malariology, 32(1), 14–23.
Reed, C. J. (1993). Drug Metabolism in the Nasal Cavity: Relevance to Toxicology. Drug Metabolism Reviews, 25(1–2), 173–205.
https://doi.org/10.3109/03602539308993975
Rehman, S., Choe, K., & Yoo, H. (2016). Review on a Traditional Herbal Medicine, Eurycoma longifolia Jack (Tongkat Ali): Its Traditional Uses, Chemistry, Evidence-Based Pharmacology and Toxicology. Molecules, 21(3), 331.
https://doi.org/10.3390/molecules21030331
Rekasih, M., Muhandri, T., Safithri, M., & Wijaya, C. H. (2021). Antihyperglycemic Activity of Java Tea-Based Functional Drink-Loaded Chitosan Nanoparticle in Streptozotocin-Induced Diabetic Rats. HAYATI Journal of Biosciences, 28(3), 212. https://doi.org/10.4308/hjb.28.3.212
S. Saranya, R. Ushakumari, Sosamma Jacob, & Babu M. Philip. (2010). Efficacy of different entomopathogenic fungi against cowpea aphid, Aphis craccivora (Koch). Journal of Biopesticides, 3(1), 138–142.
Schoepfer, A. M., Engel, A., Fattinger, K., Marbet, U. A., Criblez, D., Reichen, J., Zimmermann, A., & Oneta, C. M. (2007). Herbal does not mean innocuous: Ten cases of severe hepatotoxicity associated with dietary supplements from Herbalife® products. Journal of Hepatology, 47(4), 521–526. https://doi.org/10.1016/j.jhep.2007.06.014
Sells, D. M., Brix, A. E., Nyska, A., Jokinen, M. P., Orzech, D. P., & Walker, N. J. (2007). Respiratory Tract Lesions in Noninhalation Studies. Toxicologic Pathology, 35(1), 170–177.
https://doi.org/10.1080/01926230601059969
Silalahi, M., & Nisyawati. (2019). An ethnobotanical study of traditional steam-bathing by the Batak people of North Sumatra, Indonesia. Pacific Conservation Biology, 25(3), 266.
https://doi.org/10.1071/PC18038
Singh, G. D., Ganjoo, M., Youssouf, M. S., Koul, A., Sharma, R., Singh, S., Sangwan, P. L., Koul, S., Ahamad, D. B., & Johri, R. K. (2009). Sub-acute toxicity evaluation of an aqueous extract of Labisia pumila, a Malaysian herb. Food and Chemical Toxicology, 47(10), 2661–2665.
https://doi.org/10.1016/j.fct.2009.07.031
Skoulidis, F., Alexander, G. J. M., & Davies, S. E. (2005). Ma huang associated acute liver failure requiring liver transplantation. European Journal of Gastroenterology & Hepatology, 17(5), 581–584. https://doi.org/10.1097/00042737-200505000-00017
Sparreboom, A., Cox, M. C., Acharya, M. R., & Figg, W. D. (2004). Herbal Remedies in the United States: Potential Adverse Interactions With Anticancer Agents. Journal of Clinical Oncology, 22(12), 2489–2503.
https://doi.org/10.1200/JCO.2004.08.182
Sukalingam, K., Jaarin, K., Saad, Q. H. M., Mohamed, S., & Othman, F. (2016). Consumption of ADD-X and Repeatedly Heated Palm Oil on the Blood Pressure and Oxidative Stress Markers in Ovarectmized Rats. International Journal of Pharmacology, 12(5), 514–522.
https://doi.org/10.3923/ijp.2016.514.522
Tajul Ariff, A. S., Soelaiman, I. N., Pramanik, J., & Shuid, A. N. (2012). Effects of Eurycoma longifolia on Testosterone Level and Bone Structure in an Aged Orchidectomised Rat Model. Evidence-Based Complementary and Alternative Medicine, 2012, 1–7. https://doi.org/10.1155/2012/818072
Varlibas, F., Delipoyraz, I., Yuksel, G., Filiz, G., Tireli, H., & Gecim, N. O. (2009). Neurotoxicity following chronic intravenous use of “Russian Cocktail.” Clinical Toxicology, 47(2), 157–160. https://doi.org/10.1080/15563650802010388
Verduin M.L., & Labbate L.A. (2002). Psychosis and delirium following metabolife use. Psychopharmacol Bull., 36(3), 42–45.
Wong, A. H. C., Smith, M., & Boon, H. S. (1998). Herbal Remedies in Psychiatric Practice. Archives of General Psychiatry, 55(11), 1033.
https://doi.org/10.1001/archpsyc.55.11.1033
Wu, H., Xi, H., Lai, F., Ma, J., Chen, W., & Liu, H. (2019). Cellular antioxidant activity and Caco‐2 cell uptake characteristics of flavone extracts from Labisia pumila. International Journal of Food Science & Technology, 54(2), 536–549.
https://doi.org/10.1111/ijfs.13968
Zajmi, A., Ramli, L. H., Al-Abd, N., & Othman, Z. (2020). Anti-hyperlipidemia activity of key lime (Citrus aurantifolia) and kaffir lime (Citrus hystrix) peel extracts on high fat diet induced hyperlipidemic rats. Solid State Tech., 63, 2925–2932.
Zakaria, A. A., Noor, M. H. M., Ahmad, H., Hassim, H. A., Mazlan, M., & Latip, M. Q. A. (2021). A Review on Therapeutic Effects of Labisia pumila on Female Reproductive Diseases. BioMed Research International, 2021, 1–9.
https://doi.org/10.1155/2021/9928199
Zhang, B., Xu, D., Guo, Y., Ping, J., Chen, L., & Wang, H. (2008). Protection by and anti‐oxidant mechanism of berberine against rat liver fibrosis induced by multiple hepatotoxic factors. Clinical and Experimental Pharmacology and Physiology, 35(3), 303–309. https://doi.org/10.1111/j.1440-1681.2007.04819.x
Zhongjing Zhang, Craig Mitchell, Ye Feng, & Nigel Wiseman. (1999). On Cold Damage. Paradigm Publications.
Copyright (c) 2024 Mohamad Noor Hadi Nordin, Han Yih Lau, Mohammad Malek Faizal Azizi, Sohana Romeli
This work is licensed under a Creative Commons Attribution 4.0 International License.
All Content should be original and unpublished.