Improvement of Dissolution Properties of Etoricoxib through Solid Dispersion Technique
Downloads
Etoricoxib, a non-steroidal anti-inflammatory drug, is used to Osteoarthritis, Rheumatoid arthritis and Acute Gouty arthritis. Etoricoxib is practically insoluble in water; hence present study was carried out to enhance dissolution properties of Etoricoxib through the preparation of Solid Dispersions using Mannitol, PEG 6000 and PVP K30 as carriers at various proportions by using Solvent Evaporation Method. The drug release profile was studied in 0.1N HCl containing 0.75 % SLS. U.V. Spectrophotometric method was selected for assay as well as in-vitro dissolution studies at 234nm. The FTIR used to characterize the solid state of solid dispersions. All the solid dispersions exhibited superior dissolution than pure drug. The drug dissolution studies followed first order kinetics.
Dallob A et al. Characterization of Etoricoxib, A novel selective Cox-2 inhibitor. J.Clin. Pharmacol. 2003; 43: 573-585.
Alfred Martin, Physical pharmacy, 4th Ed, Philadelphia Lippin Cott Williams and Wilkins, (1993).
Swarbrick and Baylan Encyclopedia of Pharmaceutical technology, 2nd Ed, Marcel Dekker Inc, (2002).
Leunner C, Dressman J. Improving drug solubility for oral delivery using solid dispersions. Eur. J. Pharm Bio Pharm. 2000; 50: 47-60.
Brahmankar BM, Sunil B. Jaiswal. Biopharmaceutics and Pharmaceutics, 1st Ed, Vallabh Prakashan: 297-302, (1995).
Chiou WL, Riegelman S. Preparation and dissolution characterization of several Fast release Solid Dispersions of Griseofulvin. J. Pharm. Sci.. 1969; 58: 1505-1510.
Chiou WL, Riegelman S. Pharmaceutical applications of Solid Dispersion Systems. J. Pharma Sci.. 1971; 60: 1281-1302.
Malleshwar Rao V. S. N et al. Formulation and Characterization of Meloxicam Solid Dispersions. Indian Pharmacist. 2008; 7: 67-70.
M. M. Patel, D.M. Patel. Fast Dissolving Valdecoxib Tablets containing Solid Dispersions of Valdecoxib. IJPS. 2006; 68: 222-226.
Kamal Dua, M. et al. Dissolution Enhancement of Aceclofenac through Solid Dispersions. The Indian Pharmacist. 2002; 6: 70-72.
ST Prajapati et al. Studies to Enhance Dissolution Properties of Carbamazepine. IJPS. 2007; 69: 427-430.
P. Srinivas Babu et al. Enhancement of Dissolution rate of Glimepiride using Newer carriers. The Indian Pharmacist. 2008; 7: 65-68.
Bhanubhai N et al. Preparation and Characterization of Etoricoxib- Polyehtylene Glycol 4000 plus Polyvinyl pyrrolidone k-30 Solid Dispersions. Acta Pharm. 2006; 56: 285-298.
Raymond C Rowe and Paul J Sheskey, Paul J Waller. Hand book of Pharmaceutical Excipients, 4th Ed, The pharmaceutical press: 455, (2003) .
Liu C, Desai KG. Characterization of Rofecoxib-PEG 4000 Solid Dispersions and tablets based on Solid Disoersions. Pharma Dev Technol. 2005; 10; 467-477.
Sethi S, Squllante E. Solid Dispersions of Carbamazepine in PVPK-30 by conventional solvent evaporation and supercritical methods. Int. J. Pharma. 2004; 19: 1-10.
Loyd V et al. Dissolution rates of Hydrocartisone and Prednisone utilizing sugars Solid Dispersion systems in tablet form. J. Pharma Sci.. 2006; 67: 979-981.
Khan K.A, The concept of dissolution efficiency. J. Pharmacol. 1975;27: 48-49.
All Content should be original and unpublished.
