Inhibition of Germ Tube Formation in Mucor & Candida by JRK’s DCOD
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JRK’s DOCD is a proprietary siddha medicine, indicated for prevention of co-morbidities of diabetes. Earlier studies on the product has proven its effect in boosting the phagocyte mediated immunity. In the current study the ability of the product in preventing pathogenicity of fungi is evaluated. Germ tube formation is proven to increase the pathogenicity of the fungi than the spores alone. For this different species of fungi i.e., Candida albicans, 2 isolates of Candida dubelensis and three isolates of Mucor and 1 isolate of Rhizopus are taken. These fungal cultures when treated with the JRK’s DCOD, there is an inhibition of germ tube formation compared to control. Complete study details are presented in the paper.
Pfaller MA, Diekema DJ. 2004, Rare and Emerging Opportunistic Fungal Pathogens: Concern for Resistance beyond Candida albicans and Aspergillus fumigatus, J Clin Microbiol. 42(10): 4419–4431.
Syeda Neelam Afroze, Rajani Korlepara, Guttikonda Venkateswara Rao, Jayakiran Madala. 2017, Mucormycosis in a Diabetic Patient: A Case Report with an Insight into Its Pathophysiology, Contemp Clin Dent. 8(4): 662–666
Chian-Yong Low, Coleman Rotstein, 2011, Emerging fungal infections in immunocompromised patients, F1000 Med Rep. 2011; 3: 14. Published online 2011 Jul 1. doi: 10.3410/M3-14, PMCID: PMC3155160
Suzanne E. Geerlings, Andy I.M. Hoepelman, Immune dysfunction in patients with diabetes mellitus (DM), FEMS Immunology & Medical Microbiology, Volume 26, Issue 3-4, December 1999, Pages 259–265,
https://doi.org/10.1111/j.1574-695X.1999 .tb01397.x
Amruthavalli G.V., Aruna.V, Gayathri Rajagopal. Therapeutic Polymorphism’ of anti-diabetic herbal drug. EC Diabetes and metabolic research, Vol 5, Issue 3, 2021.
Aruna.V, Amruthavalli G.V., Gayathri Rajagopal. Why poly herbal preparation is more advantageous than targeted single molecule based drug (s) for the management of diabetes mellitus. World Journal of Pharmaceutical and Medical Research. Vol 7, Issue 1, 2021.
Aruna.V, Amruthavalli G.V., Gayathri Rajagopal. Cellular Level Catalysation of Glucose by Organ Level Cells as a Possible Therapeutic Scope for Diabetes Mellitus. International Journal of Science and Healthcare Research.Vol.6; Issue: 1; Jan.-March 2021
Soundharya.R., Aruna.V, Amruthavalli G.V., Gayathri Rajagopal. Comparison on the Anti-Diabetic Effect of NIKU Plus Versus Madhumega chooranam. Research & Reviews: A Journal of Unani, Siddha and Homeopathy,Volume 6, Issue 2.
Amruthavalli G.V., Aruna.V, Gayathri Rajagopal. Solution for Diabetes mellitus-Niku plus, Journal of Diabetes and Treatment, Volume 2019, Issue 02.
Donald C. Sheppard, Scott G. Filler. 2015, Host Cell Invasion by Medically Important Fungi, Cold Spring Harb Perspect Med. 2015 Jan; 5(1): a019687. doi: 10.1101/cshperspect.a019687, PMCID: PMC4292075
Marianne Kretschmar, Bernhard Hube, Thomas Bertsch, Dominique Sanglard, Renate Merker, Meike Schröder, Herbert Hof, Thomas Nichterlein. 1999, Germ Tubes and Proteinase Activity Contribute to Virulence of Candida albicans in Murine Peritonitis, Infect Immun. 1999 Dec; 67(12): 6637–6642. PMCID: PMC97077
Ranjit Unnikrishnan, Anoop Misra. 2020, Infections and diabetes: Risks and mitigation with reference to India, Diabetes Metab Syndr. 2020 November-December; 14(6): 1889–1894. Published online 2020 Sep 22. doi: 10.1016/j.dsx.2020.09.022, PMCID: PMC7505871
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