Synthesis and Antibacterial Activity of 4,4’-(Arylmethylene)Bis(3-Methyl-1- Phenyl-1H-Pyrazol-5-Ol) Derivatives in Presence Ce(SO4)2.4H2O as a Catalyst Under Solvent free Condition using Ultrasonication Technique

4,4’-(arylmethylene)bis(3-methyl-1- phenyl-1H-pyrazol-5-ol) derivatives, ultrasonication technique

Authors

  • Rajiv V Khobare Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad-431004, India
  • Ramkrushna P Pawar Department of Chemistry, Govt. Vidarbha Institute of Science and Humanities, Amravati-444604, India
  • Khandu D Warad Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad-431004, India
  • Amit P Tayde Shri Vijaysinha Yadav Arts and Science College, Pethvadgoan, Dist Kolhapur
  • Chandrakant B. Mane Shri Vijaysinha Yadav Arts and Science College, Pethvadgoan, Dist Kolhapur
February 14, 2020

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Mixture of aromatic aldehyde(1 mmol) and 1-phenyl-3-methyl-5-pyrazolone (2 mmol) in H2O–EtOH (1:1, 5 mL) at heating condition, was stirred thoroughly in the presence of a catalytic amount of Ce(SO4)2.4H2O (10 mg, 2.5 mol%) to afford 4,4’-(arylmethylene)bis(3-methyl-1-phenyl-pyrazol-5-ols) in excellent yields.

The synthesized derivatives were subjected for anti-bacterial activity using ciprofloxacin as standard drug against S. aureus and Pseudomonas aeruginosa using agar cup plate method. All the derivatives showed good antibacterial activity. The salient features of this method include simple procedure, mild conditions, easy purification, moderate to good yields of products and high generality.