The Study Of Lipid Profile Levels, Oxidative Stress And Thyroid Status In Thyroid Disorders
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AIM: The study was undertaken to evaluate the interaction between thyroid hormones, the lipid profile levels and role of oxidative stress in patients with thyroid disorders.
MATERIALS AND METHODS: The study includes 25controls with normal thyroid status and 30 hypothyroid cases and 20 hyperthyroid cases having duration of disease below 5years in the age group of 30 to 60 years. Thyroid status was estimated by ELISA method. Ascorbic acid by dinitrophenyl hydrazine method, cholesterol & HDL-C by CHOD-POD method, triglycerides by GPO-POD method.
RESULTS: In hypothyroidism, lipid profile levels are significantly increased and there isdecrease in F T3, F T4 and increase in TSH. In hyperthyroidism lipid profile levels are not significantly changed and increased F T3, F T4 and decreased TSH levels are observed. Both hypo and hyperthyroidism are characterized by higher levels of lipid peroxide when compared with control indicating oxidative damage.
CONCLUSION: In hypothyroidism the increase in lipid peroxide was due to increase in TSH levels, and hypercholesterolemia has a stronger influence on development of oxidative stress. In hyperthyroidism the increase in lipid peroxide was due to increase in F T4 levels
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