Blood Cells Positive Increase Regulated By Haemopoietic Stimulating Plasma Antimalarials Concentration
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Effects of varied plasma concentrations of amalar, chloroquine, cotecxin, fansidar and lapdap on blood cells and its parameters were investigated in twenty four albino rats for 28 days. There was significant difference in the plasma concentration of various antimalarials, amalar; 5.9611mg/L, chloroquine; 3.0140mg/L, cotecxin,; 1.6571mg/L, fansidar; 10.704mg/L and lapdap; 0.9601mg/L, (P<0.05). Fansidar showed the highest plasma concentration amongst all the drugs. Despite these plasma variations, chloroquine increased red blood cells, haemoglobin and packed cell volume than other drugs, (P<0.05) lapdap increased white blood cells count than others, (P<0.05) whereas, cotecxin increased platelet counts than other drugs (P<0.05). Chloroquine is found in the study to be very beneficial to blood cells development. It is also shown that the increase in blood cells and its parameters is not a function of the various increase concentration of the antimalarials but it varied haemopoietic stimulating potentials.
Bertram, G. (2004): In Basic and Clinical Pharmacology 9th
ed. New York, Chicago, Sanfrancisco, London.
Dacie, J. V., Lewis S. M., Brain J., Bates, I. (2007): In
Practical Haematology Churchill, London.
Essien, E. M. Ebhota, M. I. (1983). Platelet Secretary
activities in acute malarial plasmodium falciparum Infection.
Acta Haematol. 70(3) 183-8.
Hoffbrand, A. V. Moss, P. A. H., & Petil, J. E. (1981): In
Essential Haematology, 5th ed. Black Well Publishing.
http://www.google.com.ng/search?9=malaria+mortality.
http://scientist against malaria.net/parasite/ plasmodium.
falciparum-(2016).
Jimmy, E. O. and Udofia, A. J. (2014). Yoyo bitters. A potent
Alternative Herbal drug in the treatment of diabetes.
International Journal of Innovative Medicine and Health
Science 23:1-5.
Jimmy E. O., Sahli. I., Ademowo, O. (2003). Fibrinopeptide
A (FPA) and Fibrinogen interactions in acute Plasmodium
falciparum malaria infection Annals of Tropical Medicine and
Parasitology 9, (8) 879-881.
Jimmy, E. O., Okon, M. A. (2012). Periodic Validation of
high anti-diabetic potentials of unripe plantain in comparison
with glibenclamide and fansidar. American Journal of
Pharmacology and Toxicology, 7(1): 15-18.
Jimmy E. O., George, A. Bates, I. Bevan, D., Rutherford, I.
(1996). Immunoglobulin Gene PCR to Distinguish Hyper-
Reactive Malaria Splenomegaly from African Chronic
lymphocytic Leukaemia and Splenic Lymphoma Trans. of
Royal Society of Trop. Med. & Hygiene, 90 37-39.
Jimmy, E. O., Achelonu, E. Orji, S. (2000). Antimalaria
Dispensing pattern by patent medicine dealers. Journal of
Public Health, England. 114, 282-285.
Lucie P, Aba P, R, Odile M P, Jean, M A, Francoise, B V,
(2016). Plasmodium falciparum: multifaceted resistance to
artemisinins. Malaria Journal 15:149
Nortey D (2007) Malaria kills more than HIV/AIDS.
https://www.modernghana.com/news Robert, G. (1979).
Gastric Cytoprotective property of prostaglandin.
Gastroenterol. 77:762-769.
Unicef (2010) Unicef- Nigeria media centre,
https://www.unicef.org/nigeria/media
WHO, (2014). Antimalaria drug resistance. http://.www.
who.int/malaria/areas/drug-resistance/overview.en.
Ursos, L. M., Roepe, P. D. (2002). Chloroquine Resistance in
the Malaria Parasite, Plasmodium Falciparum. Med.Res.Rev.
(5) 465-91.
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