Fulminant Lupus Myocarditis Presenting with Cardiogenic Shock and Persistent Complete Atrioventricular Block
Downloads
Fulminant myocarditis is an uncommon but severe cardiac manifestation of systemic lupus erythematosus (SLE), which can rapidly progress to heart failure and life-threatening rhythm disturbances. We report the case of a 33-year-old woman with a recent diagnosis of SLE who developed rapidly progressive cardiac involvement leading to cardiogenic shock and complete atrioventricular block. Her condition required intensive care management, including mechanical ventilation and temporary pacing. Following treatment with high-dose corticosteroids and cyclophosphamide, a marked improvement in ventricular function was observed, with the left ventricular ejection fraction increasing from 20% to 48%. Despite this recovery, the conduction abnormality persisted. This case highlights the fulminant presentation of lupus myocarditis, the reversibility of myocardial dysfunction and the potential persistence of conduction system involvement.
Suszek D, Popławska M, Prośniak J, et al. A novel approach to cardiovascular events in patients with systemic lupus erythematosus: risk factor assessment and treatment analysis. Rheumatol Int. 2025;45(1):139.
Du Toit R, Karamchand S, Doubell AF, Reuter H, Herbst PG. Lupus myocarditis: review of current diagnostic modalities and their application in clinical practice. Rheumatology (Oxford). 2023;62(2):523–534.
Lazzerini PE, Acampa M, Cupelli M, et al. Anti-Ro/SSA antibodies blocking calcium channels as a potentially reversible cause of atrioventricular block in adults. JACC Clin Electrophysiol. 2023;9(8 Pt 3):1631–1648.
Blachut D, Przywara-Chowaniec B, Mazurkiewicz M, Tomasik A. Update: heart failure in systemic lupus erythematosus. Appl Sci. 2025;15(3):1590.
Tan S, Li L, Zhang H, Dawuti A, Rejiafu N. A rare case report: fulminant myocarditis in neonatal lupus erythematosus. Front Cardiovasc Med. 2025;12:1538903.
Lo Presti S, Elajami TK, Reyaldeen R, et al. The spectrum of lupus myocarditis: from asymptomatic forms to cardiogenic shock. Heart Fail Rev. 2021;26(6):1497–1504.
Hutman-Zahler A, Goldstein J, Anderson T, et al. A rare case of fulminant myocarditis leading to the diagnosis of systemic lupus erythematosus. JACC Case Rep. 2025;30(15):104049.
Copyright (c) 2026 Ibenchekroun Meryem, Fellat Nadia

This work is licensed under a Creative Commons Attribution 4.0 International License.
All Content should be original and unpublished.

