@article{Lushnikova_Onyan_Kostarev_Kozhikhova_Andreev_Moiseeva_2019, title={Cell Viability Reducing In Doxorubicin-Resistant Breast Cancer by Cationic Peptides}, volume={5}, url={http://rajournals.in/index.php/rajar/article/view/552}, DOI={10.33826/rajar/v5i11.02}, abstractNote={<p>Acquired resistance to various drugs is an obstacle for anticancer therapy. Doxorubicin (Dox)  is the first-line chemo-drug for therapy of various malignant tumors but it fails when treatment of multi-drug resistant tumors. One of the main factors of  Dox-resistance is over expression of drug resistance genes, particularly, P-glycoprotein – Pgp. Earlier we’ve revealed a high selective apoptosis of tumor cells, induced by some cationic peptides  (CPs) <em>in vitro</em> through inactivation their cell targets – chaperone proteins nucleolin/NCL and nucleophosmin/NPM. This paper describes effect of CPs on breast cancer (BC) cell line HBL 100 and doxorubicin-resistant cell line HBL-100/Dox.</p> <p><strong>Objective </strong>is to examine the viability of BC and Dox-resistant BC cells after incubation with CPs.</p> <p><strong>Results</strong> Some Arg/Lys-enriched cationic peptides under study  induce cell death by nucleolar stress initiation both in HBL 100 BC cell line and HBL 100/ID 120 one. Thus, these CPs are expected NCL/NPM inhibitors, which   significantly reduce viability both BC and BC doxorubicin –resistant cells in vitro.</p>}, number={11}, journal={RA Journal Of Applied Research}, author={Lushnikova, Anna A. and Onyan, Anastasia V. and Kostarev, Alexander V. and Kozhikhova, Kseniya V. and Andreev, Sergey M. and Moiseeva, Natalya I.}, year={2019}, month={Nov.}, pages={2582–2585} }