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Role of Sitagliptin and Linagliptin in Amelioration of Chronic Mild Stress in Rats

Sunita Goswami1, Priyanka Shukla2

 DOI :

 Author's Affiliations

1Associate Professor, Dept. of Pharmacology, L. M. College of Pharmacy, Navrangpura, Ahmedabad-380009, GUJARAT-INDIA

2Asst. Professor, Dept. of Pharmacology, L. J. Institute of Pharmacy, Sarkhej,  Ahmedabad-382210, GUJARAT-INDIA



Studies show that stress has a pivotal role in the development of diabetes and its complications. Patients with diabetes have an increased prevalence of anxiety and depression as compared to non-diabetic population. The pleiotropic role of Incretins has been a subject of interest in current times, including the anxiolytic and anti-depressant nature of GLP-1 and its analogues. However, no satisfactory reports are available for the role of DPP-IV inhibitors in the same. The role of DPP-IV inhibitors, Sitagliptin and Linagliptin in acute models of anxiety and depression have been investigated in our previous studies. Hence, the present study was carried out to investigate their role in a chronic model of stress (CMS) in rats. Body weight, water intake, sucrose intake, Anhedonia (% preference for sucrose) and cortisol levels were evaluated. Behavioral parameters were evaluated using the light dark box test and Porsolt’s forced swim test.  Results showed that, Sitagliptin and Linagliptin have a significant role in lowering chronic mild stress in rats as evident from increased sucrose intake and lowering of anhedonia, and cortisol levels in rats treated with Sitagliptin and Linagliptin. This suggests that DPP-IV inhibitors can possibly improve the CNS status of patients of type 2 diabetes.